NONMEM

• NLME models

Installation in macOS

• the material is based on readme_751_MACOSX.txt file from NONMEM webpage
• It worked with my MacBook (M3) with macOS Sonoma 14.5
• You'll need:
  • password to open zip file
  • licence file

Command Line Tools

• Install newest Command Line Tools in Mac OS

  # uninstall older versions
  sudo rm -rf /Library/Developer/CommandLineTools
  # install new version
  xcode-select --install
  

gfortran

• Install gfortran using homebrew

  # install homebrew
  /bin/bash -c "$(curl -fsSL https://raw.githubusercontent.com/Homebrew/install/HEAD/install.sh)"
  
  # add `/opt/homebrew/bin` (or your homebrew path) to your PATH
  ## for .zsh. (if you use bash, `nano ~/.bash_profile`)
  nano ~/.zshrc
          ## add this in the file, save changes and exit `⌃ + O, ⌃ + X`.
          export PATH="/opt/homebrew/bin:$PATH"
  ## apply the changes. (if you use bash, `source ~/.bash_profile`)
  source ~/.zshrc
  ## verify changes (homebrew path should be in listed paths)
  echo $PATH
  
  # install gcc
  brew install gcc
  
  # Add symbolic link to gcc
  ## use if it is not there
  mkdir -p ~/bin
  ## version number might change
  ln -sf /opt/homebrew/bin/gcc-14 ~/bin/gcc
  
  # check versions 
  ##to ensure that it won't use the "clang" C compiler
  export PATH=/usr/local/bin:/usr/local/gfortran/bin:$PATH
  ##gcc and GNU Fortran versions should match
  gcc --version
  gfortran --version
  

• Compiler Test for Fortran

# Create the `Compiler/test` Directory
mkdir -p ~/Compiler/test
cd ~/Compiler/test

# Create the Fortran Source File
## create and open file
nano hello.f90
        ## add this in the file, save changes and exit `⌃ + O, ⌃ + X`.
        program hello
            print *, 'Hello, NONMEM World!'
        end program hello

# Create the Makefile
## create and open file
nano Makefile
        ## add this in the file, save changes and exit `⌃ + O, ⌃ + X`.
        FC = gfortran
        FFLAGS = -O2
        TARGET = hello

        all: $(TARGET)

        $(TARGET): $(TARGET).o
            $(FC) $(FFLAGS) -o $(TARGET) $(TARGET).o

        $(TARGET).o: $(TARGET).f90
            $(FC) $(FFLAGS) -c $(TARGET).f90

        clean:
            rm -f $(TARGET) $(TARGET).o

# Run the Make Commands
make clean
make
./hello
## Uutput: `Hello, NONMEM`

# remove created folder
rm -rf ~/Compiler

Install NONMEM

• download installation files from NONMEM webpage

# Unzip zip file in terminal (you'll need password from ICON).
unzip Downloads/NONMEM751.zip
cd Downloads/nm751CD  

# Remove extra attributes
xattr -rc nm751CD 

# install nonmem
sudo /bin/bash SETUP75 ~/Downloads/nonmem751/nm751CD /opt/NONMEM/nm751 gfortran y ar same rec i

# executes the NONMEM script
cd /opt/NONMEM/nm751/run
./nmfe75 CONTROL5 REPORT5.txt -prdefault
ls -l prsame.set

# add symbolic links and aliases
ln -sf /opt/NONMEM/nm751/run/nmfe75 ~/bin/nmfe75
ln -sf /opt/NONMEM/nm751/run/nmfe75 ~/bin/nmfe                
ln -sf /opt/NONMEM/nm751/help/nmhelp ~/bin/nmhelp
alias nmhelp_web='open /opt/NONMEM/nm751/html/index.htm'

Update licence file

• it should be located in /opt/NONMEM/nm751/license/nonmem.lic

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