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Handling BLLQ data

  • Below Lower Limit of Quantification
  • not always possible to improve the LLOQ of the bioanalytical assays [📖]
  • ignoring data below LLOQ [📖]
    • biased and slightly overpredicted near or below LLOQ
  • BLQ observations should be considered if the fraction BLQ is larger than 10% [📖]
  • censoring BLQ in data with a low fraction BLQ (10%) [📖]
    • 1-CMT model: minor impact
    • 2-CMT model: more impact
  • 4 types of methods
    • the improvement depends on model complexity and fraction of observations below LLOQ [📖]

M1

  • Censoring observations below LLOQ

M2

  • [TBA]

M3

  • the likelihood for the observations below LLOQ is assessed
  • may not be possible for more complex models

M4

  • [TBA]