Skip to content

Baseline models

  • to consider the baseline values observed before and after treatment
    • e.g. endogenous synthesis of cortisol
    • e.g. endogenous biomarker (17-OHP)
  • 4 types of methods [📖]

B1

  • individual baseline was derived considering IIV (\(η_i\)) and the population baseline
  • assuming a log-normal distribution of the baseline
  • does not require pre-dose measurements
  • seen as the gold standard
  • independent of the data
  • superior to the B2 method
\[baseline_𝑖 = baseline \cdot 𝑒^{𝜂_𝑖}\]

B2

  • estimated \(baseline_i\) is informed by
    • the individually observed initial concentration (\(baseline_{obs,i}\))
    • the interindividual variability corresponding to the residual variability (\(η_i,RV\))
\[𝑏𝑎𝑠𝑒𝑙𝑖𝑛𝑒_𝑖=𝑏𝑎𝑠𝑒𝑙𝑖𝑛𝑒_{𝑜𝑏𝑠,𝑖} \cdot 𝑒^{𝜂_𝑖,𝑅𝑉}\]

B3

  • [TBA]

B4

  • [TBA]